Studies

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  1. Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study, Y. Fujita & M. Iki & J. Tamaki & K. Kouda & A. Yura & E. Kadowaki & Y. Sato & J.-S. Moon & K. Tomioka & N. Okamoto & N. Kurumatani, Osteoporos Int (2012) 23:705–714
  2. Bone quality and vitamin K2 in type 2 diabetes: Review of preclinical and clinical studies, Jun Iwamoto, Yoshihiro Sato, Tsuyoshi Takeda, and Hideo Matsumoto, Nutrition Reviews vol. 69 issue 3 March 2011. p. 162-167
  3. Calcium and vitamin D intake by postmenopausal women with osteoporosis in Spain: an observational calcium and vitamin D intake (CaVIT) study, Tao Fan, Gonzalo Nocea, Ankita Modi, Leah Stokes, Shuvayu S Sen, Global Outcomes Research, Merck & Company, Whitehouse Station, NJ, USA; Department of Outcomes Research, Merck, Sharp and Dohme Spain, Madrid, Spain; 3Global Human Health, Outcomes Research, Merck & Company, Whitehouse Station, NJ, USA
  4. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Booth SL, Tucker KL, Chen H, et al. Am J Clin Nutr. 2000;71:1201–1208.
  5. Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women, Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y, Nutritional Epidemiology Program, National Institute of Health and Nutrition, 1-23-1, Toyama, Shinjyuku-ku, Tokyo 162-8636, Japan.
  6. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study. Ikeda Y, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H (2006) J Nutr 136:1323–8
  7. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women Osteoporos. M. H. J. Knapen, L. J. Schurgers, C. Vermeer , Int. 2007, 18, 963-972
  8. Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis. Ebina K, Shi K, Hirao M, Kaneshiro S, Morimoto T, Koizumi K, Yoshikawa H, Hashimoto J. Department of Orthopaedics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  9. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG), Nobuhiro Sasaki • Eiji Kusano • Hideaki Takahashi, Yasuhiro Ando • Kazuki Yano • Eisuke Tsuda, Yasushi Asano
  10. Vitamin K intake and hip fractures in women: a prospective study. Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA. Am J Clin Nutr. 1999;69:74–79.
  11. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) Dialysis Study Investigators. J Bone Miner Res. 2012 Nov;27(11):2271-8. doi: 10.1002/jbmr.1677. Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D’Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M;
  12. Vitamin K Treatment Reduces Undercarboxylated Osteocalcin but Does Not Alter Bone Turnover, Density, or Geometry in Healthy Postmenopausal North American Women, Neil Binkley,1 Judith Harke,1 Diane Krueger,1 Jean Engelke,1 Nellie Vallarta-Ast,1 Dessa Gemar,1, Mary Checovich,1 Richard Chappell,2 and John Suttie3, JOURNAL OF BONE AND MINERAL RESEARCH, Volume 24, Number 6, 2009
  13. Vitamin K: Novel molecular mechanisms of action and its roles in osteoporosis, Kotaro Azuma, Yasuyoshi Ouchi1 and Satoshi Inoue, Departments of Geriatric Medicine and Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, and Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical School, Saitama, Japan
  14. Vitamin K status of healthy Japanese women: age-related vitamin K requirement for -carboxylation of osteocalcin1–3, Naoko Tsugawa, Masataka Shiraki, Yoshitomo Suhara, Maya Kamao, Kiyoshi Tanaka, and Toshio Okano, American Journal of Clinical Nutrition
  15. Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms1–4, Helen M Macdonald, Fiona E McGuigan, Susan A Lanham-New, William D Fraser, Stuart H Ralston, and David M Reid
  16. Vascular Calcification in Middle Age and Long-Term Risk of Hip Fracture: The Framingham Study†, Elizabeth J Samelson PhD1,2,*, L Adrienne Cupples3, Kerry E Broe1, Marian T Hannan1,2, Christopher J O’Donnell4,Douglas P Kiel1,2
  17. Osteoclast inhibitory effects of vitamin K2 alone or in combination with etidronate or risedronate in patients with rheumatoid arthritis: 2-year results. Morishita M, Nagashima M, Wauke K, Takahashi H, Takenouchi K. Department of Joint Disease and Rheumatism, Nippon Medical School, Tokyo, Japan.
  18. Osteocalcin: Skeletal and Extra-Skeletal Effects, Anna Neve, Addolorata Corrado, and Francesco Paolo Cantatore*, Department of Medical and Surgical Sciences, Rheumatology Clinic, University of Foggia, Foggia, Italy
  19. Osteoporosis and vitamin K intake, Robert E Olson, American Journal of Clinical Nutrition
  20. Relationships between undercarboxylated osteocalcin and vitamin K intakes, bone turnover, and bone mineral density in healthy women, Mika Yamauchi a, Toru Yamaguchi a,*, Kiyoko Nawata a,b, Shin Takaoka a, Toshitsugu Sugimoto , a Internal medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo-city, Shimane 693-8501, Japan, b Department of Health and Nutrition, The University of Shimane, Junior College, Matsue Campus, 7-24-2 Himenogi, Matsue-city, Shimane 690-0044, Japan
  21. Review Article Osteoporosis treatment: Focus on safety, Ian R. Reid , Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
  22. Serum level of under-carboxylated osteocalcin and bone mineral density in early menopausal Norwegian women. Emaus N, Nguyen ND, Almaas B, Berntsen GK, Center JR, Christensen M, Gjesdal CG, Grimsgaard AS, Nguyen TV, Salomonsen L, Eisman JA, Fønnebø VM. Department of Health and Care Sciences, Faculty of Health Sciences, University of Tromsø, 9037, Tromsø, Norway
  23. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women M. H. J. Knapen & N. E. Drummen & E. Smit & C. Vermeer & E. Theuwissen, Osteoporos Int 2013
  24. Treatment with vitamin k(2) combined with bisphosphonates synergistically inhibits calcification in cultured smooth muscle cells., Saito E, Wachi H, Sato F, Sugitani H, Seyama Y., Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan.
  25. Yaegashi Y, Onoda T, Tanno K, Kuribayashi T, Sakata K, Orimo H. Association of hip fracture incidence and intake of calcium, magnesium, vitamin D, and vitamin K. Eur J Epidemiol.2008;23:219–225.